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KMID : 1039920140210020114
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Neonatal Medicine
2014 Volume.21 No. 2 p.114 ~ p.121
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Optimal Ventilatory Strategies in Preterm Infants: Permissive Hypercapnia
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Hwang Jong-Hee
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Abstract
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Bronchopulmonary dysplasia associated with lung injury is an important morbidity in extremely low birth weight infants. Lung injury during mechanical ventilation is associated with high tidal volume and high end-inspiratory lung volume. Lung injury and bronchopulmonary dysplasia may be prevented with ventilatory strategies using optimal gas exchange such as permissive hypercapnia. This article will review the pathophysiologic background of lung injury and the current therapeutic ventilatory strategies such as permissive hypercapnia to reduce lung injury in preterm infants.
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KEYWORD
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Pulmonary ventilation, Bronchopulmonary dysplasia, Hypercapnia, Infant, Newborn
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